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Nitrofurantoin, trimethoprim–sulfamethoxazole, fosfomycin, and pivmecillinam are considered first-line agents for cystitis. Fluoroquinolones should not be routine first-line choices for cystitis, although they are first-line empirical therapy for pyelonephritis.
Dr. Hooton reports receiving consulting fees from Pinnacle Pharmaceuticals, Pfizer, and Alita Pharmaceuticals. No other potential conflict of interest relevant to this article was reported.
Disclosure forms provided by the author are available with the full text of this article at aguda NEJM.org.
This article (10.1056/NEJMcp1104429) was updated on March 15, 2012, at NEJM.org.
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