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Ciprofloxacin antibiotic dosage chart

Medication Dosage Form Dosing Other
Cefadroxil

(Duricef®)

Capsule
  • 500 mg ($)
  • ciprofloxacin antibiotic dosage chart
Tablet
  • 1000 mg ($-$$)
Suspension
  • 250 mg/5 ml
  • 500 mg/5 ml ($-$$)
Pediatric
  • Impetigo - 30 mg/kg/day (max 1000 mg/day) given once daily or divided into 2 doses (PI)
  • Skin infections - 30 mg/kg/day (max 1000 mg/day) given in 2 divided doses (PI)
  • Strep throat - 30 mg/kg once daily (max 1000 mg/day) for 10 days (IDSA)
  • Urinary tract infection ciprofloxacin - 30 mg/kg/day (max 1000 mg/day) given in 2 divided doses (PI)
Adults
  • Skin infections - 1000 mg/day given once daily or divided into 2 doses (PI)
  • Strep throat - 1000 mg/day given once daily or divided into 2 doses for 10 days (IDSA)
  • Urinary tract infection - 1000 - 2000 mg/day given once daily or divided into 2 doses for 3 - 7 days (IDSA, PI)
  • Cefadroxil is a first generation cephalosporin
  • May take without regard to food
  • Kidney disease (adults)
    • CrCl < 50 ml/min: dose adjustment recommended; see cefadroxil PI
Cephalexin

(Keflex®)

Capsule
  • 250 mg ($)
  • 500 mg ($)
  • 750 mg ($$$$)
Tablet
  • 250 mg
  • 500 mg ($)
Suspension
  • 125 mg/5 ml
  • 250 mg/5 ml ($)
Pediatric
  • Cellulitis (non-MRSA) - 25 - 50 mg/kg/day (max 2000 mg/day) given in 4 divided doses for 5 - 10 days (IDSA)
  • Endocarditis prophylaxis - 50 mg/kg (max 2000 mg) 30 - 60 minutes before procedure (penicillin allergic without severe reaction) (AHA)
  • Impetigo - 25 – 50 mg/kg/day (max 1000 mg/day) given in 3 – 4 divided doses for 7 days (IDSA)
  • Otitis media - 75 - 100 mg/kg/day given in 4 divided doses for 5 - 10 days (PI)
  • Strep throat - 40 mg/kg/day (max 1000 mg/day) given in 2 divided doses for 10 days (IDSA)
  • Urinary tract infection - 50 - 100 mg/kg/day (max 2000 mg/day) given in 4 divided doses for 7 - 14 days (CTE)
Adults (15 years and older)
  • Cephalexin is a first generation cephalosporin
  • May take without regard to food
  • Cephalexin is a first generation cephalosporin
  • Cephalexin may increase metformin levels
  • Kidney disease - clearance is reduced. Manufacturer makes no specific recommendation.
Cefaclor

(Ceclor®)

Capsule
  • 250 mg ($)
  • 500 mg ($)
Suspension
  • 125 mg/5 ml ($)
  • 250 mg/5 ml ($$-$$$)
  • 375 mg/5 ml ($$-$$$)
Pediatric
  • Cellulitis (non-MRSA) - 20 - 40 mg/kg/day (max 1000 mg/day) given in 3 divided doses (PI)
  • Otitis media - 40 mg/kg/day (max 1000 mg/day) given in 2 divided doses (PI)
  • Pneumonia, community-acquired - 20 - 40 mg/kg/day (max 1000 mg/day) given in 3 divided doses (PI)
  • Strep throat - 20 - 40 mg/kg/day (max 1000 mg/day) given in 2 divided doses for 10 days (PI)
  • Urinary tract infection - 20 - 40 mg/kg/day (max 1000 mg/day) given in 3 divided doses (PI)
Adults
  • Cefaclor is a second generation cephalosporin
  • Food slows absorption but does not affect the extent of absorption
  • Liver disease - manufacturer makes no dosage recommendation
  • Kidney disease - no dose adjustment necessary
Cefprozil

(Cefzil®)

Tablet
  • 250 mg
  • 500 mg ($)
Suspension
  • 125 mg/5 ml
  • 250 mg/5 ml ($-$$)
Pediatric (6 months - 12 years)
  • Cellulitis - 20 mg/kg/day (max 1000 mg/day) given once daily for 10 days (PI)
  • Otitis media - 30 mg/kg/day (max 1000 mg/day) given in 2 divided doses for 10 days (PI)
  • Pneumonia, community-acquired - 30 mg/kg/day (max 1000 mg/day) given in 2 divided doses for 7 - 10 days (IDSA)
  • Sinusitis - 15 - 30 mg/kg/day (max 1000 mg/day) given in 2 divided doses for 10 days (PI)
  • Strep throat - 15 mg/kg/day (max 500 mg/day) given in 2 divided doses for 10 days (PI)
Adolescents and Adults (age 12 years and older)
  • Cellulitis - 250 - 500 mg twice a day or 500 mg once daily for 10 days (PI)
  • Sinusitis - 250 - 500 mg twice a day for 10 days (PI)
  • Strep throat - 500 mg once daily for 10 days (PI)
  • Cefprozil is a second generation cephalosporin
  • May take without regard to food
  • Liver disease - no dose adjustment necessary
  • Kidney disease
    • CrCl ≤ 29 ml/min: - use half the standard dose
Cefuroxime

(Ceftin®)

Tablet
  • 125 mg
  • 250 mg
  • 500 mg ($)
Suspension
  • 125 mg/5 ml
  • 250 mg/5 ml ($$-$$$)
Pediatric (3 months to 12 years)
NOTE: Pediatric dosing is for suspension only. Suspension and tablet are not bioequivalent on a mg-to-mg basis.
  • Impetigo - 30 mg/kg/day (max 1000 mg/day) given in 2 divided doses for 10 days (PI)
  • Otitis media - 30 mg/kg/day (max 1000 mg/day) given in 2 divided doses for 5 - 10 days (AAP)
  • Pneumonia, community-acquired - 30 mg/kg/day (max 1000 mg/day) given in 2 divided doses for 7 - 10 days (IDSA)
  • Sinusitis - 30 mg/kg/day (max 1000 mg/day) given in 2 divided doses for a minimum of 10 days (AAP)
  • Strep throat - 20 mg/kg/day (max 500 mg/day) given in 2 divided doses for 10 days (PI)
  • Urinary tract infection - 20 - 30 mg/kg/day (max 1000 mg/day) given in 2 divided doses for 7 - 14 days (CTE)
Adolescents and Adults (13 years and older)
  • Bite, animal - Cefuroxime 500 mg twice a day +
    • Clindamycin 300 mg three times a day; OR
    • Metronidazole 250 - 500 mg three times a day (IDSA)
  • Early Lyme disease - 500 mg twice a day for 20 days (PI)
  • Gonorrhea - 1000 mg one time dose (PI)
  • Pneumonia, community-acquired - Cefuroxime 500 mg twice a day for 7 - 14 days + Macrolide (IDSA, PI)
  • Sinusitis - 250 mg twice a day for 10 days (PI)
  • Skin infections - 250 - 500 mg twice a day for 10 days (PI)
  • Strep throat - 250 mg twice a day for 10 days (PI)
  • Urinary tract infection - 250 mg twice a day for 7 days (IDSA, PI)
  • Cefuroxime is a second generation cephalosporin
  • Suspension should be taken with food
  • Tablets may be taken without regard to food
  • Tablets and suspension are not substitutable on a mg-to-mg basis
  • Kidney disease
    • CrCl ≥ 30 ml/min - no adjustment necessary
    • CrCl 10 - 29 ml/min - give standard individual dose every 24 hours
    • CrCl < 10 ml/min - give standard individual dose every 48 hours
Cefdinir

(Omnicef®)

Capsule
  • 300 mg ($)
Suspension
  • 125 mg/5 ml
  • 250 mg/5 ml ($)
Pediatric (6 months - 12 years)
  • Otitis media - 14 mg/kg/day (max 600 mg/day) given in 1 or 2 divided doses for 5 - 10 days (AAP)
  • Sinusitis - 14 mg/kg/day (max 600 mg/day) given in 1 or 2 divided doses for a minimum of 10 days (AAP)
  • Skin infections - 7 mg/kg/dose (max 300 mg/dose) twice a day for 10 days (PI)
  • Strep throat - 7 mg/kg/dose (max 300 mg/dose) twice a day for 5 to 10 days OR 14 mg/kg (max 600 mg/day) once daily for 10 days (PI)
Adults and Adolescents (Age 13 years and older)
  • Pneumonia, community-acquired - 300 mg twice a day for 10 days (PI)
  • Sinusitis - 300 mg twice a day or 600 mg once daily for 10 days (IDSA)
  • Skin infections - 300 mg twice a day for 10 days (PI)
  • Strep throat - 300 mg twice a day for 5 - 10 days or 600 mg once daily for 10 days (PI)
  • Urinary tract infection - 300 mg twice a day for 3 - 7 days (IDSA)
  • Cefdinir is a third generation cephalosporin
  • May take without regard to food
  • Iron supplements and antacids reduce cefdinir absorption. Do not take within 2 hours of each other.
  • Cefdinir and iron may cause stool to turn red
  • Liver disease - no dose adjustment necessary
  • Kidney disease
    • CrCl < 30 ml/min: adult dose is 300 mg once daily; pediatric dose is 7 mg/kg/day (max 300 mg/day) given once daily
Cefditoren

(Spectracef®)

Tablet
  • 200 mg ($$$$)
  • 400 mg ($$$$)
Adults and Adolescents (Age 12 years and older)
  • Cefditoren has been discontinued in the U.S.
  • Cefditoren is a third generation cephalosporin
  • Take with a meal to increase absorption
  • Drugs that reduce gastric acidity (e.g. antacids, H2 blockers, PPIs) decrease absorption
  • Liver disease
    • Child-Pugh A/B: no dose adjustment necessary
    • Child-Pugh C: has not been studied
  • Kidney disease
    • CrCl > 50 ml/min: No dose adjustment necessary
    • CrCl 30 - 49 ml/min: 200 mg twice a day
    • CrCl < 30 ml/min: 200 mg once daily
Cefixime

(Suprax®)

Capsule
  • 400 mg ($$$$)
Tablet, chewable
  • 100 mg
  • 150 mg
  • 200 mg ($$$$)
Tablet
  • 400 mg ($$$$)
Suspension
  • 100 mg/5 ml
  • 200 mg/5 ml
  • 500 mg/5 ml ($$$$)
Pediatric (6 months - 12 years)
  • Sinusitis - 8 mg/kg/day (max 400 mg/day) given in one or two divided doses for a minimum of 10 days. Give with clindamycin. See AAP sinusitis recs. (AAP, PI)
  • Urinary tract infection - 8 mg/kg/day (max 400 mg/day) given once daily for 7 - 14 days (CTE)
Adults and Adolescents (Age 12 years and older)
  • Gonorrhea - Cefixime - 400 mg single dose +
    • Azithromycin - 1000 mg single dose; OR
    • Doxycycline - 100 mg twice a day for 7 days (CDC)
  • Cefixime is a third generation cephalosporin
  • May take without regard to food
  • Kidney disease
    • CrCl < 60 ml/min: dose adjustment recommended; see cefixime PI for details
Cefpodoxime

(Vantin®)

Tablet
  • 100 mg
  • 200 mg ($$-$$$)
Suspension
  • 50 mg/5 ml
  • 100 mg/5 ml ($$-$$$)
Pediatric (age 2 months through 12 years)
  • Otitis media - 10 mg/kg/day (max 400 mg/day) given in 2 divided doses for 5 - 10 days (AAP)
  • Pneumonia, community-acquired - 10 mg/kg/day (max 400 mg/day) given in 2 divided doses for 7 - 10 days (IDSA)
  • Sinusitis - 10 mg/kg/day (max 400 mg/day) given in 2 divided doses for a minimum of 10 days (AAP)
  • Strep throat - 10 mg/kg/day (max 200 mg/day) given in 2 divided doses for 5 - 10 days (PI)
  • Urinary tract infection - 10 mg/kg/day (max 400 mg/day) given in 2 divided doses for 7 - 14 days (CTE)
Adolescents and Adults (age 12 years and older)
  • Cefpodoxime is a third generation cephalosporin
  • Suspension may be taken without regard to food
  • Tablets should be taken with food
  • Drugs that reduce gastric acidity (e.g. antacids, H2 blockers, PPIs) decrease absorption
  • Liver disease - no dose adjustment necessary
  • Kidney disease
    • CrCl < 30 ml/min: increase dosing interval to every 24 hours
Ceftibuten

(Cedax®)

Capsule
  • 400 mg ($$$-$$$$)
Suspension
  • 180 mg/5 ml ($$$$)
Pediatric
  • Otitis media - 9 mg/kg/day (max 400 mg/day) given once daily for 10 days (PI)
  • Strep throat - 9 mg/kg/day (max 400 mg/day) given once daily for 10 days (PI)
Adolescents and Adults (age 12 years and older)
  • Otitis media - 400 mg once daily for 10 days (PI)
  • Strep throat - 400 mg once daily for 10 days (PI)
  • Ceftibuten has been discontinued in the U.S.
  • Ceftibuten is a third generation cephalosporin
  • Ceftibuten should be taken at least 2 hours before or one hour after a meal. Food decreases absorption.
  • Liver disease - manufacturer makes no dosage recommendation
  • Kidney disease
    • CrCl > 50 ml/min: No dose adjustment necessary
    • CrCl 30 - 49 ml/min: 4.5 mg/kg/day or 200 mg once daily
    • CrCl 5 - 29 ml/min: 2.25 mg/kg/day or 100 mg once daily
Ceftriaxone

(Rocephin®)

Vial
  • 250 mg
  • 500 mg
  • 1000 mg
  • 2000 mg ($)
Pediatric
  • E. coli, enterotoxigenic - 50 mg/kg/day IM/IV given once daily for 3 days (CTE)
  • Endocarditis prophylaxis - 50 mg/kg (max 1000 mg) IM 30 - 60 minutes before procedure (AHA)
  • Otitis media - 50 mg/kg/day (max 1000 mg) IM for 1 to 3 days (AAP)
  • Pneumonia, community-acquired - 50 - 100 mg/kg/day (max 2000 mg/day) IM given once daily for 7 - 10 days (IDSA)
  • Salmonella, nontyphoidal - 100 mg/kg/day IV given in 2 divided doses for 7 - 10 days (CTE)
  • Shigella - 50 mg/kg/day IM/IV given once daily for 3 days (CTE/IDSA)
  • Skin infections - 50 - 75 mg/kg/day (max 2000 mg/day) given once a day or in two divided doses (PI)
  • Vibrio vulnificus - 50 mg/kg/day IM/IV given once daily for 3 days (CTE)
Adult
  • Diabetic foot ulcer (moderate, non-MRSA) - 1 - 2 gram(s) IM once daily for 7 - 14 days (IDSA, PI)
  • Endocarditis prophylaxis - 1 gram IM 30 - 60 minutes before procedure (AHA)
  • Epididymitis (likely caused by chlamydia or gonorrhea) Ceftriaxone 250 mg IM single dose + Doxycycline 100 mg twice a day for 10 days (CDC)
  • Gonorrhea - Ceftriaxone 250 mg IM single dose +
    • Azithromycin - 1000 mg single dose; OR
    • Doxycycline - 100 mg twice a day for 7 days (CDC)
  • Neurosyphilis (pen-allergic) - 2 grams IM/IV daily for 10 - 14 days (CDC)
  • Pneumonia, community-acquired - Ceftriaxone 1 gram IM/IV once daily for 7 - 14 days + Macrolide (IDSA, CTE)
  • Salmonella, nontyphoidal - 1 - 2 gram(s) IV once daily for 5 - 10 days (CTE/IDSA)
  • Syphilis (primary and secondary, pen-allergic) - 1 gram IM/IV daily for 10 - 14 days (CDC)
  • Ceftriaxone is a third generation cephalosporin
  • Do not give to neonates ≤ 28 days old with hyperbilirubinemia
  • Liver disease - no dose adjustment necessary
  • Kidney disease - no dose adjustment necessary
  • Kidney and liver disease (concurrent) - do not exceed 2 grams daily

Source: http://www.straighthealthcare.com/antibiotic-chart.html


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