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\ Antibiotics \
Amoxicillin is semisynthetic antibiotic in the penicillin family, a close relative of ampicillin. Amoxicillin is indicated for the treatment of the following infections:
Amoxicillin Efficacy for Strep Throat
Strep throat (bacterial pharyngitis) is caused by Streptococcus pyogenes, or group A beta-hemolytic streptococci (GABHS). GABHS accounts for about 15-30% of pharyngitis cases in children and 5-10% of cases in adults. Streptococcal pharyngitis occurs mainly in children 5 to 15 years of age, with the peak incidence during the first few years of school.
Strep throat is contagious and is spread by via the airborne route. The presence of strep bacteria can be confirmed with a throat culture.
Although strep throats are usually mild, and would often get better on their own, some untreated strep throats result in serious complications such as rheumatic fever (joint and heart disease) and post-streptococcal glomerulonephritis (inflammation of the kidneys).
Amoxicillin is very effective in the treatment of strep throat. It is convenient, inexpensive, and has relatively narrow spectrum. Streptococcus pyogenes are highly susceptible to amoxicillin and have not developed resistance to it. The IDSA's newly revised guidelines7 for Group A streptococcal pharyngitis advise that when a strep infection is confirmed by testing, it should be treated with penicillin or amoxicillin. Amoxicillin is often used in preference to penicillin V in children because of poor palatability of penicillin suspensions.
According to the recent data1 the rate of eradication of group A beta-hemolytic streptococci from the tonsils with amoxicillin is greater than 80%. In the US prospective observational study3 the elimination of strep throat symptoms was achieved in 84% of amoxicillin-treated children. Studies comparing amoxicillin with penicillin V report comparable efficacyy5.
Amoxicillin potential benefits in the treatment of streptococcal pharyngitis:
Dosage for adults: 500 mg twice a day for 10 days.
Dosage for children: <40 kg, 375 mg twice a day for 10 days; >40 kg, 500 mg twice a day for 10 days.
The maximum daily dosage for amoxicillin is 1.000 mg, although up to 1.500 mg is acceptable.
According to the recent data2, 4, once-daily amoxicillin dosing regimen is as effective as conventional twice daily regimen.
If Amoxicillin is not working for Strep Throat...
Contraindication: Amoxicillin should NOT be used when infectious mononucleosis is suspected.
Mode of action
Amoxicillin has a moderate spectrum of antibacterial activity, which includes a wide range of Gram-positive and a limited range of Gram-negative organisms.
Amoxicillin is a bactericidal antibiotic (kill the bacteria). It prevents bacterial cell wall mucopeptide synthesis by acylating the enzyme transpeptidase, thus making it unable to cross-link muramic acid containing peptidoglycan strands. This inhibition of the biosynthesis of dipeptidoglycan, a substance necessary for cell wall strength and rigidity, results in a defective cell wall.
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Written by HealthyStock.net, October 2009.
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