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Ceftazidime renal dose ciprofloxacin

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Drugs & Diseases

Brand and Other Names:Fortaz, Tazicef, more...Tazidime

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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

injectable solution

  • 20mg/mL
  • 40mg/mL

powder for injection

  • 500mg
  • 1g
  • 2g
  • 6g

more...

Bone & Joint Infections

2 g IV q12hr

Gynecologic & Intra-abdominal Infections

2 g IV q8hr for 4-7 days

Pulmonary Infections

Infections caused by Pseudomonas spp in patients with cystic fibrosis who have healthy renal function

30-50 mg/kg IV q8hr; not to exceed 6 g/day  

Meningitis

2 g IV q8hr

Pneumonia

Uncomplicated: 0.5-1 g IV q8hr

Complicated: 2 g IV q8hr

Mild Skin/Skin Structure Infections

0.5-1 g IV or IM q8hr

Urinary Tract Infections

Complicated: 500 mg IV or IM q8-12hr

Uncomplicated: 250 mg IV or IM q12hr

Life-Threatening Infections

Especially in immunocompromised patients

2 g IV q8hr

Dosing Modifications

Renal impairment

  • Modifications based on 1-g dose
  • CrCl 31-50 mL/min: 1 g q12hr
  • CrCl 16-30 mL/min: 1 g q24hr
  • CrCl 6-15 mL/min: 500 mg q24hr
  • CrCl <5 mL/min: 500 mg q48hr

Dosing Considerations

Susceptible organisms

  • Citrobacter spp, Clostridium spp, Enterobacter spp, Escherichia coli, Haemophilus influenzae, Klebsiella spp, Moraxella catarrhalis, Neisseria meningitidis, Proteus mirabilis, Pseudomonas spp, Serratia spp, Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes

Dosage Forms & Strengths

injectable solution

  • 20mg/mL
  • 40mg/mL

powder for injection

  • 500mg
  • 1g
  • 2g
  • 6g

more...

Infections Caused by Susceptible Organisms

<1 month: Safety and efficacy not established

1 month-12 years: 30-50 mg/kg IV q8hr; not to exceed 6 g/day (higher end of dosing range reserved for patietns with immunocompromise, meningitis, or cystic fibrosis) 

>12 years: 1-2 g IV q8hr

Dosing Considerations

Use sodium carbonate preparation

Usual dosing range for neonates (per manufacturer)

  • <28 days: 30 mg/kg IV q12hr  

Usual dosing range for neonates (per American Academy of Pediatrics)

  • 7-28 days: 50 mg/kg IV q8hr
  • <7 days, <2 kg: 50 mg/kg IV q12hr
  • <7 days, >2 kg: 50 mg/kg IV q8-12hr

Interactions

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Adverse Effects

1-10%

Transient increases in transaminases (3-9%)

Eosinophilia (<7%)

Diarrhea (<2%)

Immune hypersensitivity reaction (2%)

Phlebitis (<2%)

Rash (maculopapular or erythematous) (2%)

Thrombocytosis (2%)

Injection site pain (1%)

<1%

Abdominal pain

Agranulocytosis

Angioedema

Asterixis

Coma

Dizziness

Encephalopathy

Fever

Hallucinations

Increased serum concentrations of bilirubin

Leukopenia

Lymphocytosis

Metallic taste

Myoclonia

Nausea or vomiting

Neuromuscular excitability

Neutropenia

Paresthesia

Photosensitivity

Pruritus

Seizures

Thrombocytopenia

Transient increases in blood urea nitrogen (BUN) or serum creatinine

Urticaria

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Warnings

Contraindications

Documented hypersensitivity to drug or components

Cautions

High and prolonged serum ceftazidime concentrations can occur from usual dosages in patients with transient or persistent reduction of urinary output because of renal insufficiency; elevated levels of in these patients can lead to, seizures, nonconvulsive status epilepticus encephalopathy, coma, asterixis, neuromuscular excitability, and myoclonia

Elevated international normalized ratio (INR) has reported in patients with nutritional deficiency, prolonged treatment, or renal or hepatic disease

Use with caution in patients with history of seizure disorder (especially in renal impairment, where drug levels may increase significantly)

Modify dose in renal impairment

Use with caution in patients with history of penicillin allergy

Bacterial or fungal overgrowth of nonsusceptible organisms may occur with prolonged or repeated therapy

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Pregnancy & Lactation

Pregnancy category: B

Lactation: Drug excreted in breast milk; use with caution

Pregnancy Categories

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Pharmacology

Mechanism of Action

Third-generation cephalosporin with broad-spectrum gram-negative activity, including Pseudomonas; has lower efficacy against gram-positive organisms and higher efficacy against resistant organisms; arrests bacterial growth by binding to 1 or more penicillin-binding proteins, thereby, in turn, inhibiting final transpeptidation step of peptidoglycan synthesis in bacterial cell-wall synthesis and inhibiting cell-wall biosynthesis

Absorption

Peak plasma time: IM, 1 hr

Distribution

Widely distributed to body tissues and fluids, including aqueous humor, ascitic and prostatic fluids, and bone; penetrates CSF when meninges are inflamed

Protein bound: 5-24%

Metabolism

Not metabolized

Elimination

Half-life: 1-2 hr

Dialyzable: Hemodialysis, yes; peritoneal dialysis, yes

Excretion: Urine (80-90% as unchanged drug)

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Administration

IV Incompatibilities

Additive: Amikacin, aminophylline, ciprofloxacin, gentamicin, ranitidine

Y-site: Amiodarone, amphotericin B cholesteryl complex, azithromycin, amsacrine, clarithromycin, cisatracurium(?), doxorubicin liposome, erythromycin lactobionate, fluconazole(?), idarubucin, midazolam, nicardipine (incompatible at ceftazidime 125 mg/mL but compatible at ceftazidime 10 mg/mL), pentamidine, propofol (incompatible at ceftazidime 125 mg/mL but compatible at ceftazidime 40 mg/mL), sagramostim(?), vancomycin(?), warfarin

IV/IM Administration

IV

  • Direct injection: Inject over 3-5 minutes directly into vein or through tubing of running compatible infusion solution
  • Infusion: Infuse intermittently over 15-30 minutes

IM

  • Inject deeply

Storage

Store intact vials at room temperature, protected from light

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Images

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Patient Handout

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Formulary

FormularyPatient Discounts

To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

Create Your List of Plans

Adding plans allows you to:

  • View the formulary and any restrictions for each plan.
  • Manage and view all your plans together – even plans in different states.
  • Compare formulary status to other drugs in the same class.
  • Access your plan list on any device – mobile or desktop.

The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

View explanations for tiers and restrictions

Tier Description
1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC NOT COVERED – Drugs that are not covered by the plan.
Code Definition
PA Prior Authorization
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL Quantity Limits
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST Step Therapy
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR Other Restrictions
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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